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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
27.58
Human Site:
Y81
Identified Species:
40.44
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
Y81
G
D
G
M
E
R
D
Y
R
A
I
P
E
L
D
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
G85
L
D
A
Y
E
A
E
G
L
A
L
D
D
E
D
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
Y81
G
D
G
M
E
R
D
Y
R
A
I
P
E
L
D
Dog
Lupus familis
XP_541736
1001
113024
Y179
G
D
G
M
E
R
D
Y
R
A
I
P
E
L
D
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
Y81
G
D
G
M
E
R
D
Y
R
P
I
P
E
L
D
Rat
Rattus norvegicus
NP_001101343
905
102125
Y82
G
D
G
M
E
R
D
Y
R
P
I
P
E
L
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
Y89
G
D
G
M
E
R
D
Y
R
A
I
P
E
L
D
Chicken
Gallus gallus
NP_001006139
888
100332
G80
L
D
V
Y
E
A
E
G
L
A
L
D
D
E
D
Frog
Xenopus laevis
P55861
886
100243
E76
I
S
E
L
D
R
Y
E
V
E
G
L
D
D
E
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
E76
V
P
E
L
D
R
Y
E
A
E
G
L
D
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
D78
M
P
E
L
D
H
Y
D
P
A
L
L
D
D
E
Honey Bee
Apis mellifera
XP_395109
1005
114136
Y190
G
D
N
M
E
A
D
Y
R
P
M
P
E
L
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
F39
Y
R
Q
L
I
T
Q
F
R
N
F
I
R
D
F
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
R76
R
V
I
P
E
L
D
R
F
D
P
D
N
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
D48
H
R
L
I
I
G
M
D
D
L
R
N
H
N
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
Y82
D
D
N
M
Y
E
D
Y
A
A
D
H
N
R
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
26.6
100
100
N.A.
93.3
93.3
N.A.
100
26.6
6.6
13.3
N.A.
6.6
73.3
6.6
20
P-Site Similarity:
100
46.6
100
100
N.A.
93.3
93.3
N.A.
100
46.6
33.3
33.3
N.A.
40
80
20
26.6
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
40
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
19
0
0
13
50
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
63
0
0
19
0
57
13
7
7
7
19
32
19
75
% D
% Glu:
0
0
19
0
63
7
13
13
0
13
0
0
44
19
13
% E
% Phe:
0
0
0
0
0
0
0
7
7
0
7
0
0
0
7
% F
% Gly:
44
0
38
0
0
7
0
13
0
0
13
0
0
0
0
% G
% His:
7
0
0
0
0
7
0
0
0
0
0
7
7
0
0
% H
% Ile:
7
0
7
7
13
0
0
0
0
0
38
7
0
7
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
13
0
7
25
0
7
0
0
13
7
19
19
0
44
7
% L
% Met:
7
0
0
50
0
0
7
0
0
0
7
0
0
0
0
% M
% Asn:
0
0
13
0
0
0
0
0
0
7
0
7
13
7
0
% N
% Pro:
0
13
0
7
0
0
0
0
7
19
7
44
0
0
0
% P
% Gln:
0
0
7
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
7
13
0
0
0
50
0
7
50
0
7
0
7
7
0
% R
% Ser:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
7
7
7
0
0
0
0
0
7
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
13
7
0
19
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _